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GPR137B Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GPR137B Antibody (C-Terminus) ALS10165
    Anti-GPR137B antibody IHC of human kidney.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession O60478
Reactivity Human, Mouse, Rabbit, Monkey, Pig, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (5-12 µg/ml)
Additional Information
Gene ID 7107
Other Names Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein, GPR137B, TM7SF1
Target/Specificity Human GPR137B / TM7SF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR137B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR137B
Synonyms TM7SF1 {ECO:0000303|PubMed:22729905}
Function Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).
Cellular Location Lysosome membrane; Multi-pass membrane protein. Note=Colocalized with MTOR in lysosome after amino acid stimulation.
Tissue Location Expressed in kidney, heart, brain and placenta.
Volume 50 µl
Research Areas
Citations (0)
citation

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References

Spangenberg C.,et al.Genomics 48:178-185(1998).
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 467.50
Cat# ALS10165
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