|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Hamster, Monkey, Pig, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR|
|Target/Specificity||Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM28 (41%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRPR Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Corjay M.H.,et al.J. Biol. Chem. 266:18771-18779(1991).
Xiao D.,et al.Gene 264:95-103(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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