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GRM1 / MGLUR1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GRM1 / MGLUR1 Antibody (N-Terminus) ALS10194
    Anti-GRM1 / MGLUR1 antibody ALS10194 IHC of human brain, neurons and glia.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q13255
Reactivity Human, Rabbit, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 132kDa
Dilution IHC-P (17 µg/ml)
Additional Information
Gene ID 2911
Other Names Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Target/Specificity Human GRM1 / MGLUR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGRM1 / MGLUR1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM1
Synonyms GPRC1A, MGLUR1
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain..
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

References

Desai M.A.,et al.Mol. Pharmacol. 48:648-657(1995).
Stephan D.,et al.Neuropharmacology 35:1649-1660(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Guergueltcheva V.,et al.Am. J. Hum. Genet. 91:553-564(2012).
Wu H.,et al.Science 344:58-64(2014).

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$ 467.50
Cat# ALS10194
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