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GRM5 / MGLUR5 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GRM5 / MGLUR5 Antibody (C-Terminus) ALS10199
    Anti-GRM5 / MGLUR5 antibody ALS10199 IHC of human brain, neurons and glia.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P41594
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 132kDa
Dilution IHC-P (16 µg/ml)
Additional Information
Gene ID 2915
Other Names Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5
Target/Specificity Human GRM5 / MGLUR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CDC42EP5 (69%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGRM5 / MGLUR5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM5
Synonyms GPRC1E, MGLUR5
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Cellular Location Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

References

Minakami R.,et al.Biochem. Biophys. Res. Commun. 199:1136-1143(1994).
Katsuki F.,et al.Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
Levinthal C.,et al.Abstr. - Soc. Neurosci. 25:976-976(1999).
Taylor T.D.,et al.Nature 440:497-500(2006).
Minakami R.,et al.Biochem. Biophys. Res. Commun. 194:622-627(1993).

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$ 395.00
Cat# ALS10199
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