|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine|
|Dilution||IHC-P (16 µg/ml)|
|Other Names||Metabotropic glutamate receptor 3, mGluR3, GRM3, GPRC1C, MGLUR3|
|Target/Specificity||Human GRM3 / MGLUR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM3 / MGLUR3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala|
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Makoff A.,et al.Brain Res. Mol. Brain Res. 40:55-63(1996).
Sartorius L.J.,et al.J. Neurochem. 96:1139-1148(2006).
Hillier L.W.,et al.Nature 424:157-164(2003).
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