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GRM7 / MGLUR7 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q14831 |
| Reactivity | Human, Mouse, Rabbit, Monkey, Chicken, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 102kDa |
| Dilution | IHC-P (4-6 µg/ml) |
| Gene ID | 2917 |
|---|---|
| Other Names | Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7 |
| Target/Specificity | Human GRM7 / MGLUR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM4 (50%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GRM7 / MGLUR7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRM7 |
|---|---|
| Synonyms | GPRC1G, MGLUR7 |
| Function | G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
References
Makoff A.,et al.Brain Res. Mol. Brain Res. 40:165-170(1996).
Flor P.J.,et al.Neuropharmacology 36:153-159(1997).
Wu S.,et al.Brain Res. Mol. Brain Res. 53:88-97(1998).
Schulz H.L.,et al.Neurosci. Lett. 326:37-40(2002).
Bolonna A.A.,et al.Schizophr. Res. 47:99-103(2001).
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