|Reactivity||Human, Mouse, Rabbit, Monkey, Chicken, Horse, Bovine, Dog|
|Dilution||IHC-P (4-6 µg/ml)|
|Other Names||Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7|
|Target/Specificity||Human GRM7 / MGLUR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM4 (50%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM7 / MGLUR7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4|
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
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Flor P.J.,et al.Neuropharmacology 36:153-159(1997).
Wu S.,et al.Brain Res. Mol. Brain Res. 53:88-97(1998).
Schulz H.L.,et al.Neurosci. Lett. 326:37-40(2002).
Bolonna A.A.,et al.Schizophr. Res. 47:99-103(2001).
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