|Reactivity||Human, Mouse, Monkey, Horse|
|Dilution||IHC-P (7-18 µg/ml)|
|Other Names||Metabotropic glutamate receptor 8, mGluR8, GRM8, GPRC1H, MGLUR8|
|Target/Specificity||Human GRM8 / MGLUR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM8 / MGLUR8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Scherer S.W.,et al.Genomics 44:232-236(1997).
Wu S.,et al.Brain Res. Mol. Brain Res. 53:88-97(1998).
Malherbe P.,et al.Brain Res. Mol. Brain Res. 67:201-210(1999).
Stormann T.M.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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