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NTSR1 / NTR Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - NTSR1 / NTR Antibody (C-Terminus) ALS10214
    Anti-NTSR1 antibody ALS10214 IHC of human brain, neurons and glia.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P30989
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (52 µg/ml)
Additional Information
Gene ID 4923
Other Names Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH, NTSR1, NTRR
Target/Specificity Human NTSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsNTSR1 / NTR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTSR1
Synonyms NTRR
Function G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).
Cellular Location Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts
Tissue Location Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.
Research Areas
Citations (0)

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Background

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

References

Vita N.,et al.FEBS Lett. 317:139-142(1993).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Swift S.L.,et al.Cancer Res. 70:347-356(2010).
Heakal Y.,et al.Cancer Biol. Ther. 12:427-435(2011).

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$ 395.00
Cat# ALS10214
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