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PTGER3 / EP3 Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - PTGER3 / EP3 Antibody (Cytoplasmic Domain) ALS10226
    Anti-PTGER3 / EP3 antibody ALS10226 IHC of human brain, cerebellum.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P43115
Reactivity Human, Mouse, Rabbit, Monkey, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (4 µg/ml)
Additional Information
Gene ID 5733
Other Names Prostaglandin E2 receptor EP3 subtype, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, PGE2-R, Prostanoid EP3 receptor, PTGER3
Target/Specificity Human PTGER3 / EP3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsPTGER3 / EP3 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTGER3
Function Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid- induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels
Research Areas
Citations (0)
citation

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Background

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

References

Adam M.,et al.FEBS Lett. 338:170-174(1994).
Schmid A.,et al.Eur. J. Biochem. 228:23-30(1995).
Yang J.,et al.Biochem. Biophys. Res. Commun. 198:999-1006(1994).
Kunapuli S.P.,et al.Biochem. J. 298:263-267(1994).
An S.,et al.Biochemistry 33:14496-14502(1994).

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$ 467.50
Cat# ALS10226
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