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ADGRB3 Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - ADGRB3 Antibody (Cytoplasmic Domain) ALS10229
    Anti-BAI3 antibody ALS10229 IHC of human brain, neurons.
    detail
  • IHC - ADGRB3 Antibody (Cytoplasmic Domain) ALS10229
    Anti-BAI3 antibody IHC of human Brain, Glioblastoma.
    detail
  • IHC - ADGRB3 Antibody (Cytoplasmic Domain) ALS10229
    Anti-BAI3 antibody IHC of human Skin, Melanoma.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O60242
Reactivity Human, Mouse, Rabbit, Monkey, Chicken, Xenopus, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 172kDa
Dilution IHC-P (7-18 µg/ml)
Additional Information
Gene ID 577
Other Names Brain-specific angiogenesis inhibitor 3, BAI3, KIAA0550
Target/Specificity Human BAI3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsADGRB3 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADGRB3 (HGNC:945)
Synonyms BAI3, KIAA0550
Function Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.

References

Shiratsuchi T.,et al.Cytogenet. Cell Genet. 79:103-108(1997).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 467.50
Cat# ALS10229
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