|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (13 µg/ml)|
|Other Names||Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2, SSTR1|
|Target/Specificity||Human SSTR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||SSTR1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Yamada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992).
Kopatz S.A.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Schwaerzler A.,et al.J. Biol. Chem. 275:9557-9562(2000).
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