FP / PTGFR Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, ICC |
---|---|
Primary Accession | P43088 |
Reactivity | Human, Monkey, Horse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 40kDa |
Dilution | IHC-P (4-8 µg/ml) |
Gene ID | 5737 |
---|---|
Other Names | Prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, Prostanoid FP receptor, PTGFR |
Target/Specificity | Human PTGFR. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | FP / PTGFR Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTGFR |
---|---|
Function | Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Eye.. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
References
Abramovitz M.,et al.J. Biol. Chem. 269:2632-2636(1994).
Kunapuli P.,et al.J. Biol. Chem. 272:27147-27154(1997).
Kopatz S.A.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Vielhauer G.A.,et al.Arch. Biochem. Biophys. 421:175-185(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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