|Reactivity||Human, Mouse, Rabbit, Monkey, Pig|
|Dilution||IHC-P (1-3 µg/ml)|
|Other Names||Rhodopsin, Opsin-2, RHO, OPN2|
|Target/Specificity||Human RHO / Rhodopsin. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||Rhodopsin / RHO Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.|
|Cellular Location||Membrane; Multi-pass membrane protein Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia|
|Tissue Location||Rod shaped photoreceptor cells which mediates vision in dim light|
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Provided below are standard protocols that you may find useful for product applications.
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
Nathans J.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:4851-4855(1984).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bennett J.,et al.Gene 167:317-320(1995).
Al-Maghtheh M.,et al.Hum. Mutat. 2:249-255(1993).
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