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Rhodopsin / RHO Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - Rhodopsin / RHO Antibody (Extracellular Domain) ALS10253
    Anti-RHO / Rhodopsin antibody ALS10253 IHC of human eye, retina.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P08100
Reactivity Human, Mouse, Rabbit, Monkey, Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution IHC-P (1-3 µg/ml)
Additional Information
Gene ID 6010
Other Names Rhodopsin, Opsin-2, RHO, OPN2
Target/Specificity Human RHO / Rhodopsin. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsRhodopsin / RHO Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RHO
Synonyms OPN2
Function Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia
Tissue Location Rod shaped photoreceptor cells which mediate vision in dim light
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.

References

Nathans J.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:4851-4855(1984).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bennett J.,et al.Gene 167:317-320(1995).
Al-Maghtheh M.,et al.Hum. Mutat. 2:249-255(1993).

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$ 467.50
Cat# ALS10253
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