|Dilution||IHC-P (5 µg/ml)|
|Other Names||C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1|
|Target/Specificity||Human CCR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CCR1 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CMKBR1, CMKR1, SCYAR1|
|Function||Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed in different hematopoietic cells|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Neote K.,et al.Cell 72:415-425(1993).
Gao J.-L.,et al.J. Exp. Med. 177:1421-1427(1993).
Nomura H.,et al.Int. Immunol. 5:1239-1249(1993).
Ko J.,et al.FASEB J. 18:890-892(2004).
Sung H.J.,et al.Exp. Mol. Med. 40:332-338(2008).
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