|Reactivity||Human, Mouse, Hamster, Monkey|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||G-protein coupled receptor 64, Human epididymis-specific protein 6, He6, GPR64, HE6, TM7LN2|
|Target/Specificity||Human GPR64. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADGRG2 / GPR64 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR64, HE6, TM7LN2|
|Function||Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein|
|Tissue Location||Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.|
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Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
Osterhoff C.,et al.DNA Cell Biol. 16:379-389(1997).
Obermann H.,et al.Mol. Reprod. Dev. 64:13-26(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
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