|Application ||IHC-P, E|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||D(3) dopamine receptor, Dopamine D3 receptor, DRD3|
|Target/Specificity||Human DRD3 / Dopamine Receptor D3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||DRD3 / Dopamine Receptor D3 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells|
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Provided below are standard protocols that you may find useful for product applications.
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Giros B.,et al.C. R. Acad. Sci. III, Sci. Vie 311:501-508(1990).
Schmauss C.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8942-8946(1993).
Liu K.,et al.J. Biol. Chem. 269:29220-29226(1994).
Fishburn C.S.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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