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ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) ALS10366
    Anti-CCRL1 / CCR11 antibody IHC of human spleen.
  • IHC - ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) ALS10366
    Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Breast, Carcinoma.
  • IHC - ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) ALS10366
    Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Colon, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NPB9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Dilution IHC-P (24-32 µg/ml)
Additional Information
Gene ID 51554
Other Names Atypical chemokine receptor 4, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR, ACKR4, CCBP2, CCR11, CCRL1, VSHK1
Target/Specificity Human CCRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACKR4
Synonyms CCBP2, CCR11, CCRL1, VSHK1
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Cellular Location Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane
Tissue Location Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Volume 50 µl
Research Areas
Citations (0)

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Background

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

References

Khoja H.,et al.Gene 246:229-238(2000).
Schweickart V.L.,et al.J. Biol. Chem. 275:9550-9556(2000).
Gosling J.,et al.J. Immunol. 164:2851-2856(2000).
Kopatz S.A.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10366
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