|Dilution||IHC-P (4-13 µg/ml)|
|Other Names||Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3|
|Target/Specificity||Human TSH Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LHCGR (42%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||TSH Receptor / TSHR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690)|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Nagayama Y.,et al.Biochem. Biophys. Res. Commun. 165:1184-1190(1989).
Libert F.,et al.Biochem. Biophys. Res. Commun. 165:1250-1255(1989).
Misrahi M.,et al.Biochem. Biophys. Res. Commun. 166:394-403(1990).
Frazier A.L.,et al.Mol. Endocrinol. 4:1264-1276(1990).
Graves P.N.,et al.Biochem. Biophys. Res. Commun. 187:1135-1143(1992).
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