ADAMTS5 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9UNA0 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 102kDa |
Dilution | IHC-P (20 µg/ml) |
Gene ID | 11096 |
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Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, 3.4.24.-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS5, ADAMTS11, ADMP2 |
Target/Specificity | Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
Precautions | ADAMTS5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADAMTS5 |
---|---|
Synonyms | ADAMTS11, ADMP2 |
Function | Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
References
Abbaszade I.,et al.J. Biol. Chem. 274:23443-23450(1999).
Hattori M.,et al.Nature 405:311-319(2000).
Hurskainen T.L.,et al.J. Biol. Chem. 274:25555-25563(1999).
Wang L.W.,et al.J. Biol. Chem. 284:30004-30015(2009).
Mosyak L.,et al.Protein Sci. 17:16-21(2008).
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