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ADAMTS5 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - ADAMTS5 Antibody (Internal) ALS10390
    Anti-ADAMTS5 antibody ALS10390 IHC of human placenta.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9UNA0
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 102kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 11096
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, 3.4.24.-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS5, ADAMTS11, ADMP2
Target/Specificity Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsADAMTS5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAMTS5
Synonyms ADAMTS11, ADMP2
Function Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

References

Abbaszade I.,et al.J. Biol. Chem. 274:23443-23450(1999).
Hattori M.,et al.Nature 405:311-319(2000).
Hurskainen T.L.,et al.J. Biol. Chem. 274:25555-25563(1999).
Wang L.W.,et al.J. Biol. Chem. 284:30004-30015(2009).
Mosyak L.,et al.Protein Sci. 17:16-21(2008).

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$ 467.50
Cat# ALS10390
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