|Reactivity||Human, Monkey, Horse, Dog|
|Dilution||IHC-P (2.6 µg/ml)|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 18.104.22.168, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688|
|Target/Specificity||Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAMTS8 (53%).|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||ADAMTS4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)|
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Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Tortorella M.D.,et al.Science 284:1664-1666(1999).
Wainwright S.D.,et al.Matrix Biol. 25:317-320(2006).
Sawaji Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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