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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GPR132 / G2A Antibody (C-Terminus)   

GPR132 / G2A Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GPR132 / G2A Antibody (C-Terminus) ALS10414
    Anti-GPR132 / G2A antibody ALS10414 IHC of human lung.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9UNW8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 29933
Other Names Probable G-protein coupled receptor 132, G2 accumulation protein, GPR132, G2A
Target/Specificity Human GPR132 / G2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DNAH8 (50%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR132 / G2A Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR132
Synonyms G2A
Function May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity)
Tissue Location Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
Volume 50 µl
Research Areas
Citations (0)

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Background

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity.

References

Weng Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:12334-12339(1998).
Ogawa A.,et al.J. Pharmacol. Exp. Ther. 332:469-478(2010).
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10414
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