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GPR83 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GPR83 Antibody (C-Terminus) ALS10415
    Anti-GPR83 antibody IHC of human brain, cortex, neurons.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NYM4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (14-28 µg/ml)
Additional Information
Gene ID 10888
Other Names Probable G-protein coupled receptor 83, G-protein coupled receptor 72, GPR83, GPR72, KIAA1540
Target/Specificity Human GPR83. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR83 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR83 (HGNC:4523)
Function G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731}
Tissue Location Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor. Could be a neuropeptide Y receptor.

References

Parker R.,et al.Biochim. Biophys. Acta 1491:369-375(2000).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS10415
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