|Dilution||IHC-P (10 µg/ml)|
|Other Names||Psychosine receptor, G-protein coupled receptor 65, T-cell death-associated gene 8 protein, GPR65, TDAG8|
|Target/Specificity||Human GPR65. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except VCL (50%), CPS1 (39%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR65 / TDAG8 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells.
Kyaw H.,et al.DNA Cell Biol. 17:493-500(1998).
Heilig R.,et al.Nature 421:601-607(2003).
Im D.-S.,et al.J. Cell Biol. 153:429-434(2001).
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