|Dilution||IHC-P (14-28 µg/ml)|
|Other Names||Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR, G-protein coupled receptor GPCR135, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor, RXFP3, RLN3R1, SALPR|
|Target/Specificity||Human RXFP3. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except VGLL4 (45%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||RXFP3 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Matsumoto M.,et al.Gene 248:183-189(2000).
Kopatz S.A.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Liu C.,et al.J. Biol. Chem. 278:50754-50764(2003).
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