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GPBAR1 / TGR5 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GPBAR1 / TGR5 Antibody (C-Terminus) ALS10473
    Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8TDU6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution IHC-P (6-16 µg/ml)
Additional Information
Gene ID 151306
Other Names G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37, GPBAR1, TGR5
Target/Specificity Human TGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPBAR1 / TGR5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPBAR1
Synonyms TGR5
Function Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

References

Maruyama T.,et al.Biochem. Biophys. Res. Commun. 298:714-719(2002).
Kawamata Y.,et al.J. Biol. Chem. 278:9435-9440(2003).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10473
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