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FPR1 / FPR Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - FPR1 / FPR Antibody (Extracellular Domain) ALS10505
    Anti-FPR1 antibody ALS10505 IHC of human spleen, red pulp.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P21462
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 2357
Other Names fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor, FPR1
Target/Specificity Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsFPR1 / FPR Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FPR1
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456).
Cellular Location Cell membrane; Multi- pass membrane protein
Tissue Location Neutrophils.
Volume 75 µl
Research Areas
Citations (0)

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Background

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456).

References

Boulay F.,et al.Biochem. Biophys. Res. Commun. 168:1103-1109(1990).
Boulay F.,et al.Biochemistry 29:11123-11133(1990).
Murphy P.M.,et al.J. Biol. Chem. 266:12560-12567(1991).
Bao L.,et al.Genomics 13:437-440(1992).
Perez H.D.,et al.Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10505
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