|Reactivity||Human, Rabbit, Hamster, Monkey, Dog|
|Dilution||IHC-P (3 µg/ml)|
|Other Names||Hydroxycarboxylic acid receptor 1, G-protein coupled receptor 104, G-protein coupled receptor 81, HCAR1, GPR104, GPR81, HCA1|
|Target/Specificity||Human GPR81. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||FKSG80 / GPR81 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR104, GPR81, HCA1|
|Function||Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.
Lee D.K.,et al.Gene 275:83-91(2001).
Liu C.,et al.J. Biol. Chem. 284:2811-2822(2009).
Wang Y.-G.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
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