|Reactivity||Human, Rabbit, Monkey, Pig, Horse, Dog|
|Dilution||IHC-P (4 µg/ml)|
|Other Names||G-protein coupled receptor 124, Tumor endothelial marker 5, GPR124, KIAA1531, TEM5|
|Target/Specificity||Human GPR124. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR125 (82%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADGRA2 / GPR124 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.|
|Tissue Location||Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).|
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Provided below are standard protocols that you may find useful for product applications.
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).
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Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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