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NR2E1 / TLX Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - NR2E1 / TLX Antibody (N-Terminus) ALS10552
    Anti-NR2E1 antibody ALS10552 IHC of human brain, neurons and glia.
  • IHC - NR2E1 / TLX Antibody (N-Terminus) ALS10552
    Anti-NR2E1 / TLX antibody IHC of human Lung, Small Cell Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9Y466
Reactivity Human, Rabbit, Monkey, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5.5 µg/ml)
Additional Information
Gene ID 7101
Other Names Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX
Target/Specificity Human NR2E1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsNR2E1 / TLX Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2E1
Synonyms TLX
Function Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Tissue Location Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Research Areas
Citations (0)

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Background

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.

References

Jackson A.,et al.Genomics 50:34-43(1998).
Kobayashi M.,et al.Mol. Cell. Biol. 20:8731-8739(2000).
Hua F.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 395.00
Cat# ALS10552
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