|Application ||WB, IHC-P, ICC|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2, ADRB2R, B2AR|
|Target/Specificity||Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADRB2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Chung F.-Z.,et al.FEBS Lett. 211:200-206(1987).
Kobilka B.K.,et al.J. Biol. Chem. 262:7321-7327(1987).
Schofield P.R.,et al.Nucleic Acids Res. 15:3636-3636(1987).
Kobilka B.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:46-50(1987).
Emorine L.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6995-6999(1987).
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