|Application ||WB, IHC-P, ICC|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2, ADRB2R, B2AR|
|Target/Specificity||Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADRB2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).|
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Provided below are standard protocols that you may find useful for product applications.
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Chung F.-Z.,et al.FEBS Lett. 211:200-206(1987).
Kobilka B.K.,et al.J. Biol. Chem. 262:7321-7327(1987).
Schofield P.R.,et al.Nucleic Acids Res. 15:3636-3636(1987).
Kobilka B.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:46-50(1987).
Emorine L.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6995-6999(1987).
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