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SMO / Smoothened Antibody (1st Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - SMO / Smoothened Antibody (1st Extracellular Domain) ALS10565
    Human, Testis: Formalin-Fixed Paraffin-Embedded (FFPE)
  • IHC - SMO / Smoothened Antibody (1st Extracellular Domain) ALS10565
    Anti-SMO / Smoothened antibody IHC of human Ovary, Carcinoma.
  • IHC - SMO / Smoothened Antibody (1st Extracellular Domain) ALS10565
    Anti-SMO / Smoothened antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q99835
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 86kDa
Dilution IHC-P (1:400)
Additional Information
Gene ID 6608
Other Names Smoothened homolog, SMO, Protein Gx, SMO, SMOH
Target/Specificity Human SMO. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSMO / Smoothened Antibody (1st Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMO
Synonyms SMOH
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium
Volume 50 µl
Research Areas
Citations (0)

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Background

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

References

Stone D.M.,et al.Nature 384:129-134(1996).
Xie J.,et al.Nature 391:90-92(1998).
Jiang N.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10565
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