|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey|
|Dilution||IHC-P (8 µg/ml)|
|Other Names||Xenotropic and polytropic retrovirus receptor 1, Protein SYG1 homolog, Xenotropic and polytropic murine leukemia virus receptor X3, X-receptor, XPR1, SYG1, XR|
|Target/Specificity||Human XPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||XPR1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed:27080106).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.|
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May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.
Yang Y.-L.,et al.Nat. Genet. 21:216-219(1999).
Tailor C.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999).
Battini J.-L.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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