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SLC5A11 / SMIT2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - SLC5A11 / SMIT2 Antibody (Internal) ALS10590
    Anti-SLC5A11 antibody ALS10590 IHC of human liver.
    detail
  • IHC - SLC5A11 / SMIT2 Antibody (Internal) ALS10590
    Anti-SLC5A11 antibody ALS10590 IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8WWX8
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 74kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 115584
Other Names Sodium/myo-inositol cotransporter 2, Na(+)/myo-inositol cotransporter 2, Sodium-dependent glucose cotransporter, Sodium/glucose cotransporter KST1, Sodium/myo-inositol transporter 2, SMIT2, Solute carrier family 5 member 11, SLC5A11 {ECO:0000312|EMBL:EAW55781.1}
Target/Specificity Human SLC5A11. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSLC5A11 / SMIT2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A11 (HGNC:23091)
Function Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro- inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway (PubMed:15172003, PubMed:18069935). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).
Cellular Location Membrane; Multi- pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q9Z1F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z1F2}. Note=Located on apical membrane of enterocytes (By similarity). Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2}
Tissue Location Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

References

Roll P.,et al.Gene 285:141-148(2002).
Mount D.B.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Bruss M.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).

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Discontinued
Cat# ALS10590
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