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SLC5A10 / SGLT5 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | A0PJK1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 125206 |
|---|---|
| Other Names | Sodium/glucose cotransporter 5, Na(+)/glucose cotransporter 5, Solute carrier family 5 member 10, SLC5A10, SGLT5 |
| Target/Specificity | Human SLC5A10. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SLC5A1 (67%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SLC5A10 / SGLT5 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC5A10 |
|---|---|
| Synonyms | SGLT5 {ECO:0000303|PubMed:24573086} |
| Function | [Isoform 1]: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:24573086, PubMed:22212718, PubMed:23451068). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:22212718, PubMed:23451068). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q5SWY8}; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed at high levels in kidney. Very low expression is detected in testes [Isoform 2]: The most abundant isoform expressed in kidney. [Isoform 5]: Expressed in kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Grempler R.,et al.FEBS Lett. 586:248-253(2012).
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