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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P22736 |
| Reactivity | Human, Monkey, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 3164 |
|---|---|
| Other Names | Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1 |
| Target/Specificity | Human NUR77. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | NR4A1 / NUR77 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR4A1 |
|---|---|
| Synonyms | GFRP1, HMR, NAK1 |
| Function | Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Fetal muscle and adult liver, brain and thyroid |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
References
Nakai A.,et al.Mol. Endocrinol. 4:1438-1443(1990).
Chang C.,et al.J. Steroid Biochem. 34:391-395(1989).
Ohkura N.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Kobayashi T.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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