|Dilution||IHC-P (16 µg/ml)|
|Other Names||Neuropeptide FF receptor 2, G-protein coupled receptor 74, G-protein coupled receptor HLWAR77, Neuropeptide G-protein coupled receptor, NPFFR2, GPR74, NPFF2, NPGPR|
|Target/Specificity||Human NPFFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NPFF2 / NPFFR2 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR74, NPFF2, NPGPR|
|Function||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.|
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Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
Cikos S.,et al.Biochem. Biophys. Res. Commun. 256:352-356(1999).
Elshourbagy N.A.,et al.J. Biol. Chem. 275:25965-25971(2000).
Bonini J.A.,et al.J. Biol. Chem. 275:39324-39331(2000).
Parker R.M.C.,et al.Brain Res. Mol. Brain Res. 77:199-208(2000).
Liu Q.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
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