|Dilution||IHC-P (10 µg/ml)|
|Other Names||Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8|
|Target/Specificity||Human NET1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ARHGEF3 (60%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NET1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Chan A.M.-L.,et al.Oncogene 12:1259-1266(1996).
Shen X.,et al.J. Biol. Chem. 276:15362-15368(2001).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Srougi M.C.,et al.PLoS ONE 6:E17108-E17108(2011).
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