|Dilution||IHC-P (10 µg/ml)|
|Other Names||Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8|
|Target/Specificity||Human NET1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ARHGEF3 (60%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NET1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Chan A.M.-L.,et al.Oncogene 12:1259-1266(1996).
Shen X.,et al.J. Biol. Chem. 276:15362-15368(2001).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Srougi M.C.,et al.PLoS ONE 6:E17108-E17108(2011).
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