|Reactivity||Human, Rabbit, Monkey, Horse, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||P2Y purinoceptor 12, P2Y12, ADP-glucose receptor, ADPG-R, P2T(AC), P2Y(AC), P2Y(cyc), P2Y12 platelet ADP receptor, P2Y(ADP), SP1999, P2RY12, HORK3|
|Target/Specificity||Human P2RY12 / P2Y12. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CACNA1F (56%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||P2RY12 / P2Y12 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Hollopeter G.,et al.Nature 409:202-207(2001).
Zhang F.L.,et al.J. Biol. Chem. 276:8608-8615(2001).
Takasaki J.,et al.Mol. Pharmacol. 60:432-439(2001).
Reinscheid R.K.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Bruess M.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
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