|Reactivity||Human, Rabbit, Monkey, Horse, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||P2Y purinoceptor 12, P2Y12, ADP-glucose receptor, ADPG-R, P2T(AC), P2Y(AC), P2Y(cyc), P2Y12 platelet ADP receptor, P2Y(ADP), SP1999, P2RY12, HORK3|
|Target/Specificity||Human P2RY12 / P2Y12. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CACNA1F (56%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||P2RY12 / P2Y12 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Hollopeter G.,et al.Nature 409:202-207(2001).
Zhang F.L.,et al.J. Biol. Chem. 276:8608-8615(2001).
Takasaki J.,et al.Mol. Pharmacol. 60:432-439(2001).
Reinscheid R.K.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Bruess M.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
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