|Dilution||IHC-P (12-24 µg/ml)|
|Other Names||Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144, HRH4, GPCR105|
|Target/Specificity||Human HRH4 / Histamine H4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||HRH4 / Histamine H4 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node|
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Provided below are standard protocols that you may find useful for product applications.
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Oda T.,et al.J. Biol. Chem. 275:36781-36786(2000).
Nakamura T.,et al.Biochem. Biophys. Res. Commun. 279:615-620(2000).
Jones P.G.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Liu C.,et al.Mol. Pharmacol. 59:420-426(2001).
Morse K.L.,et al.J. Pharmacol. Exp. Ther. 296:1058-1066(2001).
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