|Application ||IHC-P, ICC, E|
|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144, HRH4, GPCR105|
|Target/Specificity||Human HRH4 / Histamine H4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||HRH4 / Histamine H4 Receptor Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Oda T.,et al.J. Biol. Chem. 275:36781-36786(2000).
Nakamura T.,et al.Biochem. Biophys. Res. Commun. 279:615-620(2000).
Jones P.G.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Liu C.,et al.Mol. Pharmacol. 59:420-426(2001).
Morse K.L.,et al.J. Pharmacol. Exp. Ther. 296:1058-1066(2001).
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