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EDNRA / Endothelin A Receptor Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P25101 |
| Reactivity | Human, Mouse, Rabbit, Pig, Sheep, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 1909 |
|---|---|
| Other Names | Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA |
| Target/Specificity | Human Endothelin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | EDNRA / Endothelin A Receptor Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EDNRA (HGNC:3179) |
|---|---|
| Synonyms | ETA, ETRA |
| Function | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
References
Adachi M.,et al.Biochem. Biophys. Res. Commun. 180:1265-1272(1991).
Cyr C.,et al.Biochem. Biophys. Res. Commun. 181:184-190(1991).
Hosoda K.,et al.FEBS Lett. 287:23-26(1991).
Arai H.,et al.Jpn. Circ. J. 56:1303-1307(1992).
Elshourbagy N.A.,et al.J. Biol. Chem. 268:3873-3879(1993).
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