|Dilution||IHC-P (20 µg/ml)|
|Other Names||Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R|
|Target/Specificity||Human TACR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||TACR3 / NK3R Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Huang R.-R.C.,et al.Biochem. Biophys. Res. Commun. 184:966-972(1992).
Buell G.,et al.FEBS Lett. 299:90-95(1992).
Takahashi K.,et al.Eur. J. Biochem. 204:1025-1033(1992).
Kopatz S.A.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Topaloglu A.K.,et al.Nat. Genet. 41:354-358(2009).
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