|Application ||IHC-P, E|
|Dilution||IHC-P (40 µg/ml)|
|Other Names||Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor, PTGER2|
|Target/Specificity||Human EP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTGER4 (50%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||PTGER2 / EP2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Placenta and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Regan J.W.,et al.Mol. Pharmacol. 46:213-220(1994).
Oakley C.J.,et al.Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
Smock S.L.,et al.Gene 237:393-402(1999).
Warren C.N.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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