GPR1 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P46091 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41kDa |
Dilution | IHC-P (15-20 µg/ml) |
Gene ID | 2825 |
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Other Names | G-protein coupled receptor 1, GPR1 |
Target/Specificity | Human GPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LONRF2 (47%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | GPR1 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CMKLR2 (HGNC:4463) |
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Function | Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822) {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:27716822} |
Tissue Location | Expressed in hippocampus. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
References
Marchese A.,et al.Genomics 23:609-618(1994).
Martin A.L.,et al.Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
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