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GRM6 / MGLUR6 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GRM6 / MGLUR6 Antibody (N-Terminus) ALS10777
    Anti-GRM6 / MGLUR6 antibody ALS10777 IHC of human eye, retina.
  • IHC - GRM6 / MGLUR6 Antibody (N-Terminus) ALS10777
    Anti-GRM6 / MGLUR6 antibody IHC of human Ovary, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O15303
Reactivity Human, Mouse, Rabbit, Hamster, Monkey, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 95kDa
Dilution IHC-P (12 µg/ml)
Additional Information
Gene ID 2916
Other Names Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6
Target/Specificity Human GRM6 / MGLUR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (73%), GRM4 (67%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGRM6 / MGLUR6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM6
Synonyms GPRC1F, MGLUR6
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Cellular Location Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane
Tissue Location Detected in melanocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

References

Hashimoto T.,et al.Eur. J. Neurosci. 9:1226-1235(1997).
Schmutz J.,et al.Nature 431:268-274(2004).
Devi S.,et al.Pigment Cell Melanoma Res. 26:348-356(2013).
Dryja T.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:4884-4889(2005).
Sjoeblom T.,et al.Science 314:268-274(2006).

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$ 395.00
Cat# ALS10777
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