|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rabbit, Monkey, Pig|
|Dilution||IHC-P (19 µg/ml)|
|Other Names||Metabotropic glutamate receptor 4, mGluR4, GRM4, GPRC1D, MGLUR4|
|Target/Specificity||Human GRM4 / MGLUR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM4 / MGLUR4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus No expression detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Makoff A.,et al.Brain Res. Mol. Brain Res. 37:239-248(1996).
Wu S.,et al.Brain Res. Mol. Brain Res. 53:88-97(1998).
Flor P.J.,et al.Neuropharmacology 34:149-155(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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