|Application ||WB, IHC-P|
|Dilution||IHC-P (26-130 µg/ml)|
|Other Names||Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2, RXFP2, GPR106, GREAT, LGR8|
|Target/Specificity||Human RXFP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||RXFP2 / LGR8 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR106, GREAT, LGR8|
|Function||Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
Hsu S.Y.,et al.Science 295:671-674(2002).
Gorlov I.P.,et al.Hum. Mol. Genet. 11:2309-2318(2002).
Muda M.,et al.Mol. Hum. Reprod. 11:591-600(2005).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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