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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   FZD8 / Frizzled 8 Antibody (N-Terminus)   

FZD8 / Frizzled 8 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - FZD8 / Frizzled 8 Antibody (N-Terminus) ALS10781
    Anti-FZD8 / Frizzled 8 antibody IHC of human Lymph Node, Hodgkins Lymphoma.
  • IHC - FZD8 / Frizzled 8 Antibody (N-Terminus) ALS10781
    Anti-FZD8 / Frizzled 8 antibody ALS10781 IHC of human pancreas, islet of Langerhans.
  • IHC - FZD8 / Frizzled 8 Antibody (N-Terminus) ALS10781
    Anti-FZD8 / Frizzled 8 antibody IHC of human Lung, Non-Small Cell Carcinoma.
  • IHC - FZD8 / Frizzled 8 Antibody (N-Terminus) ALS10781
    Anti-FZD8 / Frizzled 8 antibody IHC of human Ovary, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9H461
Reactivity Human, Mouse, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Dilution IHC-P (30 µg/ml)
Additional Information
Gene ID 8325
Other Names Frizzled-8, Fz-8, hFz8, FZD8
Target/Specificity Human FZD8 / Frizzled 8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsFZD8 / Frizzled 8 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD8
Function Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Cellular Location Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.
Tissue Location Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

References

Saitoh T.,et al.Int. J. Oncol. 18:991-996(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Semenov M.V.,et al.Curr. Biol. 11:951-961(2001).
Li X.,et al.Protein Sci. 15:2149-2158(2006).
Hao H.X.,et al.Nature 485:195-200(2012).

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$ 395.00
Cat# ALS10781
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