|Application ||IHC-P, E|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||G-protein coupled receptor 126, Developmentally regulated G-protein-coupled receptor, Vascular inducible G protein-coupled receptor, GPR126, DREG, VIGR|
|Target/Specificity||Human GPR126. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR64 (50%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADGRG6 / GPR126 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein|
|Tissue Location||Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).
Stehlik C.,et al.FEBS Lett. 569:149-155(2004).
Moriguchi T.,et al.Genes Cells 9:549-560(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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