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ADGRG6 / GPR126 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ADGRG6 / GPR126 Antibody (N-Terminus) ALS10785
    Anti-GPR126 antibody ALS10785 IHC of human prostate.
  • IHC - ADGRG6 / GPR126 Antibody (N-Terminus) ALS10785
    Anti-GPR126 antibody ALS10785 IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q86SQ4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 137kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 57211
Other Names G-protein coupled receptor 126, Developmentally regulated G-protein-coupled receptor, Vascular inducible G protein-coupled receptor, GPR126, DREG, VIGR
Target/Specificity Human GPR126. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR64 (50%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsADGRG6 / GPR126 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADGRG6 (HGNC:13841)
Function G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).
Cellular Location Cell membrane; Multi- pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein
Tissue Location Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).

References

Stehlik C.,et al.FEBS Lett. 569:149-155(2004).
Moriguchi T.,et al.Genes Cells 9:549-560(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10785
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