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FZD7 / Frizzled 7 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - FZD7 / Frizzled 7 Antibody (N-Terminus) ALS10790
    Anti-FZD7 / Frizzled 7 antibody IHC of human Prostate, Carcinoma.
  • IHC - FZD7 / Frizzled 7 Antibody (N-Terminus) ALS10790
    Anti-FZD7 / Frizzled 7 antibody IHC of human Skin, Melanoma.
  • IHC - FZD7 / Frizzled 7 Antibody (N-Terminus) ALS10790
    Anti-FZD7 / Frizzled 7 antibody ALS10790 IHC of human heart, cardiac myocytes.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O75084
Reactivity Human, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 8324
Other Names Frizzled-7, Fz-7, hFz7, FzE3, FZD7
Target/Specificity Human FZD7 / Frizzled 7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsFZD7 / Frizzled 7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD7
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

References

Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sagara N.,et al.Biochem. Biophys. Res. Commun. 252:117-122(1998).
Kwon H.S.,et al.Mol. Cell. Biol. 29:2139-2154(2009).

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$ 395.00
Cat# ALS10790
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